Roundfin High-Profile Microtome Blade Holder
1. Dedicated high-profile design — factory-configured for high-profile blades (Feather A35/H35/N35, Thermo MX35, Leica 819)
2. 304 stainless steel construction with fully welded and polished finish for corrosion resistance and easy decontamination
3. Anti-vibration screw-lock clamping mechanism with even pressure distribution for chatter-free sectioning from 0.5 µm to 60 µm
4. Universal dovetail mount compatible with Roundfin, Leica RM series, Thermo HM series, and Sakura microtomes
5. Tool-free blade change system — insert, clamp, and section in under 30 seconds
6. Fully autoclavable at 121°C; resistant to xylene, ethanol, and paraffin solvents
Product Overview
The Roundfin High-Profile Microtome Blade Holder is a dedicated single-profile blade clamping system engineered exclusively for high-profile microtome blades. Factory-configured for precise high-profile blade geometry, it provides rigid, vibration-free blade retention essential for producing consistent ribbon sections from paraffin-embedded tissue blocks. The holder is constructed from 304 stainless steel with a fully welded and polished finish, ensuring corrosion resistance and easy decontamination in histology laboratory environments.
Roundfin High-Profile Microtome Blade Holder — dedicated clamp for high-profile disposable blades
Key Takeaway: A dedicated single-profile holder factory-calibrated for high-profile microtome blades. Not a universal holder — this model is optimized specifically for high-profile blade geometry to deliver maximum sectioning consistency and minimal vibration artifact at all thickness settings from 0.5 µm to 60 µm.
Technical Specifications
| Parameter | Specification |
|---|---|
| Blade Compatibility | High-profile microtome blades only (Feather A35, H35, N35; Thermo MX35 Ultra; Leica 819; Sakura Accu-Edge HP) |
| Material | 304 stainless steel, fully welded and polished |
| Clamping Mechanism | Screw-lock with even pressure distribution; anti-slip blade seat for vibration-free sectioning |
| Microtome Compatibility | Roundfin RD-315, RD-335, RD-355AT; Leica RM series; Thermo HM series; Sakura Accu-Cut; universal dovetail mount |
| Section Thickness | 0.5 µm to 60 µm (dependent on microtome) |
| Weight | ~0.45 kg |
| Sterilization | Fully autoclavable at 121°C; resistant to xylene, ethanol, and standard lab cleaning agents |
Key Features
- Dedicated High-Profile Geometry — Factory-configured exclusively for high-profile blades; not a universal holder, ensuring optimal blade angle and sectioning quality for dense and calcified tissues.
- Rigid Anti-Vibration Clamping — Screw-lock mechanism with even pressure distribution eliminates blade chatter and vibration artifacts at all sectioning speeds.
- 304 Stainless Steel Construction — Fully welded and polished for corrosion resistance, chemical compatibility, and long service life in busy histology labs.
- Universal Dovetail Mount — Compatible with Roundfin, Leica RM series, Thermo HM series, Sakura, and most major rotary microtome brands worldwide.
- Quick Blade Replacement — Tool-free blade change system; insert, clamp, and start sectioning in under 30 seconds with minimal downtime between blocks.
- Fully Autoclavable — Withstands standard autoclave cycles at 121°C; compatible with xylene, ethanol, and paraffin cleaning protocols.
FAQ
Can this holder accommodate low-profile blades?
No. This is a dedicated high-profile blade holder factory-configured exclusively for high-profile blades. Using low-profile blades in this holder will result in incorrect blade angle, poor section quality, and potential tissue compression. For low-profile blades, use the Roundfin Low-Profile Blade Holder. For labs that use both blade types, the Roundfin DualFit holder supports both profiles.
Which microtome brands does this holder fit?
The holder uses a standard dovetail mount compatible with Roundfin (RD-315, RD-335, RD-355AT), Leica RM series, Thermo Scientific HM series, and Sakura Accu-Cut microtomes. The universal dovetail interface ensures broad compatibility across major histology microtome platforms worldwide.
What is the difference between high-profile and low-profile blades?
High-profile blades have a taller blade body (typically 8-10 mm exposed) providing greater rigidity for dense or calcified tissues. Low-profile blades have a shorter blade body (typically 5-7 mm exposed) offering finer clearance angles for delicate specimens. High-profile blades are preferred for routine paraffin sections of firm tissues; low-profile for serial sectioning and delicate specimens. The correct holder must match the blade profile for optimal results.
How should the blade holder be cleaned between specimens?
Remove the blade, disassemble the clamping surfaces, and clean with xylene or a suitable solvent to remove paraffin residue. Follow with 70% ethanol for disinfection. The fully welded and polished stainless steel construction resists pitting and corrosion from repeated cleaning cycles. For deep decontamination, the entire holder assembly can be autoclaved at 121°C.
