Roundfin High-Profile Microtome Blade Holder
1. Dedicated single-profile design — factory-configured for high-profile blades only (NOT universal)
2. Compatible with Thermo Scientific (Microm), Leica, Sakura, and most standard rotary microtomes
3. Safe horizontal lateral blade shift mechanism prevents accidental operator contact during handling
4. 3-Zone full-edge utilization extends blade life — each edge divided into three cutting zones
5. Precision screw-lock clamping delivers firm, vibration-free blade retention for consistent sectioning
6. Stainless steel corrosion-resistant construction — separate low-profile model available separately
Product Overview
The Roundfin High-Profile Microtome Blade Holder is a precision-engineered, dedicated single-profile blade holder designed specifically for high-profile disposable microtome blades. This is a fixed-profile holder — it is optimized for one blade type, providing superior clamping stability and repeatable cutting performance compared to universal holders that compromise between profiles.

Roundfin Single-Profile Blade Holder — dedicated high-profile configuration for optimal clamping precision
Important — Single-Profile Holder: This blade holder is factory-configured for high-profile blades ONLY. It is NOT a universal dual-profile holder. If you require a blade holder that accommodates both low-profile and high-profile blades in a single unit, Roundfin offers a separate Universal Dual-Profile Blade Holder model. For low-profile blades, see our separate Low-Profile Blade Holder. The dedicated single-profile design provides superior clamping precision — eliminating the mechanical play introduced by adjustable-profile mechanisms.
Key Specifications at a Glance
Blade Profile: High-Profile (Dedicated) | Compatibility: Thermo / Leica / Sakura Microtomes | Blade Movement: Horizontal Lateral Shift | Edge Utilization: 3-Zone Full-Edge
Technical Specifications
| Product | High-Profile Microtome Blade Holder (Single-Profile) |
| Blade Profile | High-Profile (dedicated, not adjustable) |
| Low-Profile Version | Available as separate model — NOT interchangeable with this holder |
| Microtome Compatibility | Thermo Scientific (Microm), Leica, Sakura, and most standard rotary microtomes |
| Lateral Blade Shift | Horizontal movement for safety — blade retracts away from specimen during handling |
| 3-Zone Edge Utilization | Each blade edge divided into 3 equal cutting zones for full-edge utilization |
| Material | Stainless steel body with precision-machined clamping surface |
| Blade Clamping | Screw-lock mechanism — firm, vibration-free blade retention |
| Compatible Blade Brands | Feather, Leica, Thermo, Sakura, Roundfin — all standard high-profile disposable blades |
| Warranty | Manufacturing defect replacement |
Key Features
- Dedicated High-Profile Clamping — Factory-configured for high-profile blades only. No adjustment mechanism to introduce mechanical play — superior section consistency compared to universal holders that accept both profiles.
- Safe Lateral Blade Shift — The blade holder moves horizontally away from the specimen during block changes and blade handling, preventing accidental contact between operator and cutting edge.
- 3-Zone Full Edge Utilization — Each disposable blade edge is divided into three equal cutting zones. Shift the blade laterally to use a fresh zone, maximizing usable cutting length and reducing consumable costs per section.
- Broad Microtome Compatibility — Compatible with Thermo Scientific (Microm), Leica, Sakura, and most standard rotary microtomes using a standard mounting interface.
- Precision Screw-Lock Clamping — Firm, vibration-free blade retention ensures consistent section thickness across the entire cutting stroke with no blade chatter.
- Stainless Steel Construction — Corrosion-resistant body withstands daily exposure to sectioning debris, cleaning agents, and laboratory environments.
Low-Profile vs High-Profile Blade Holder Comparison
| Feature | Low-Profile Holder | High-Profile Holder (This Product) |
|---|---|---|
| Blade Type | Low-profile disposable blades only | High-profile disposable blades only |
| Best For | Labs standardized on low-profile blades; routine histology; diagnostic labs | Labs standardized on high-profile blades; thicker sections; dense tissue types |
| Blade Stability | Optimized for thinner low-profile blade geometry | Optimized for thicker high-profile blade geometry with added rigidity |
| Typical Applications | Routine paraffin sections 3-5 um; diagnostic H&E | Thicker sections 5-10 um; dense or fibrous tissue; research specimens |
FAQ
Can this blade holder accept low-profile blades?
No. This is a dedicated single-profile holder factory-configured for high-profile blades only. The clamping geometry and retention mechanism are fixed for high-profile blade dimensions. A separate low-profile blade holder model is available — see Roundfin Low-Profile Microtome Blade Holder. For a holder that accepts both profiles in one unit, see Roundfin's Universal Dual-Profile Blade Holder.
When should I choose high-profile blades over low-profile?
High-profile blades have a thicker, more rigid blade geometry that provides greater stability when cutting denser or more fibrous tissue specimens. They are preferred for thicker sections (5-10 um), difficult tissue types, and applications where maximum blade stability is required. Low-profile blades are typically used for routine 3-5 um paraffin sections.
Is this compatible with my microtome?
The blade holder is compatible with most standard rotary microtomes using a standard mounting interface, including Thermo Scientific (Microm HM series), Leica (RM series), and Sakura microtomes. Contact Roundfin with your microtome model number to confirm compatibility before ordering.
What blade brands are compatible?
All standard high-profile disposable microtome blades are compatible — including Feather, Leica, Thermo Scientific, Sakura, and Roundfin blades. The screw-lock clamping mechanism accommodates the standard high-profile blade dimensions used by all major manufacturers.
Order the Correct Blade Holder for Your Lab
This holder is factory-configured for high-profile blades only — providing the best possible clamping stability for labs that standardize on this blade type. A low-profile version and a Universal Dual-Profile model are available separately.
Contact our team: Specify your microtome model and preferred blade profile — we will confirm the correct holder for your setup within 12 hours.








